Table 2.
Amino acid substitutions in antigenic sites of A(H1N1)pdm09 influenza viruses within the period between 2009 and 2017.
| Antigenic Site | Substitution | The Name of the Isolate in Which the Substitution Was Discovered | Number of Isolates in Each Group | Total Number of Isolates Identified |
|---|---|---|---|---|
| Sa | S162T | A/Dnipropetrovsk438,441,443,444,448/2015 | 5 | 136 |
| S162T | All isolates from group 6B.1 | 55 | ||
| K163Q | All isolates beginning with A/Ukraine/312/2013 | 91 | ||
| K163I | A/Zaporizza/417/2013 | 1 | ||
| Sb | S185T | All isolates beginning with A/Ukraine/3/2011 | 93 | |
| A186T | A/Dnipropetrovsk/445/2010, A/Ukraine/60/2011 |
2 | ||
| S190G | A/Sumy/797/2009 | 1 | ||
| S190R | A/Khmelnitsky/88/2016 | 1 | ||
| Ca1 | S203T | All isolates beginning with A/Lviv/N6/2009 | 123 | |
| R205K | A/Ukraine/123/2010, A/Astrakhan/1/2011, A/Ukraine/434/2015 |
3 | ||
| E235V | A/Ukraine/3/2011 | 1 | ||
| E235D | A/Ukraine/368/2015 | 1 | ||
| S236P | A/Zaporizza/631/2016 | 1 | ||
| Ca2 | P137H | A/Ukraine/414/2015 | 1 | |
| H138R | A/Ukraine/523/2012, A/Ukraine/3/2013, A/Hong Kong/5659/2012 |
3 | ||
| A141T | A/Khmelnitsky/675,727,760/2016 | 1 | ||
| D222G | A/Kyiv/251/2009, A/Cherkasy/744/2009, A/Lviv/N6/2009, A/Sumy/797/2009, A/Rivne/596/2009, A/Volin/226/2009, A/Zakarpatska/831/2009, A/Ternopil/N11/2009, A/Dnipro/580/2016 |
9 | ||
| D222N | A/Chernivtsi/844/2009, A/Christchurch/16/2010 |
2 | ||
| Cb | A73S | A/Kharkiv/963/2016 | 1 | |
| S74R | A/Ukraine/130/2011, A/Odessa/166/2017 |
2 | ||
| S74N | A/Khmelnitsky/671/2016 | 1 |