A	adenylation domain	MBC	minimum bactericidal concentration
ABC	ATP-binding cassette	MIC	minimum inhibitory concentration
ACP	acyl carrier protein	MLSB	macrolide–lincosamide–streptogramin B
AHBA	3-amino 5-hydroxybenzoic acid	MOA	mode of action
ARO	aromatase	MRSA	methicillin-resistant Staphylococcus aureus
AT	acyltransferase	MT	methyltransferase domain
BGC	biosynthetic gene cluster	NADPH	nicotinamide adenine dinucleotide phosphate
C	condensation domain	NGST	Next Generation Sequencing Technologies
CABP	community-acquired bacterial pneumonia	NMR	nuclear magnetic resonance
CCR	crotonyl-CoA carboxylase/reductase	NRPS	nonribosomal peptide synthetase
CDI	Clostridioides difficile infection	NTG	N-methyl-N′-nitro-N-nitrosoguanidine
CLF	chain elongation factor	ORF	open reading frame
CoA	coenzyme A	PCP	peptidyl carrier protein
cryo EM	cryogenic electron microscopy	PCR	polymerase chain reaction
CYC	cyclase	PKS	polyketide synthase
DEBS	deoxyerythronolide B synthase	PTC	peptidyl transferase center
DH	dehydratase	RNA	ribonucleic acid
DNA	deoxyribonucleic acid	RNAP	RNA polymerase
dTDP	deoxythymidine diphosphate	rRNA	ribosomal RNA
E	epimerisation domain	SAM	S-adenosyl methionine
ER	enoyl reductase	SAR	structure activity relationship
ESBL	extended spectrum β-lactamase	SARP	Streptomyces antibiotic regulatory protein
FDA	Food and Drug Administration	Spp.	Species
GDP	guanosine diphosphate	TB	Tuberculosis
GI	gastrointestinal	TDP	thymidine diphosphate
Kb	kilobase	TE	Thioesterase
KR	ketoreductase	tRNA	transfer RNA
KS	ketosynthase	VRE	vancomycin-resistant Enterococci
LSAP	Lincosamide–streptogramin A–pleuromutilin	VRSA	vancomycin-resistant Staphylococcus aureus
MAC	Mycobacterium avium-intracellulare complex	WHO	World Health Organisation