Table 6.
Antibacterial activities of berberine derivatives against P. aeruginosa.
| Strain | MIC (µg/mL) for AMK in the Presence of: | MIC (µg/mL) for 13-o-MBB in the Presence of: | FIC | Mode of Interaction | ||
| − | 13-o-MBB | − | AMK | |||
| PAGUg1931 | 1 | 1 | 256 | 256 | 2.0 | Indifferent |
| PAGUg1927 | 8 | 2 | 512 | 128 | 0.5 | Synergy |
| PAGUg1659 | 16 | 8 | >512 | >512 | >1.5 | Indifferent |
| PAGU 1606 | 256 | 16 | >512 | 64 | <0.5 | Synergy |
| Strain | MIC (µg/mL) for AMK in the Presence of: | MIC (µg/mL) for Berberne in the Presence of: | FIC | Mode of Interaction | ||
| − | Berberine | − | AMK | |||
| PAGUg1931 | 1 | 1 | >512 | >512 | >2.0 | Indifferent |
| PAGUg1927 | 8 | 4 | >512 | 512 | <1.0 | Synergy or Addition |
| PAGUg1659 | 16 | 8 | >512 | >512 | 1.5 | Indifferent |
| PAGU 1606 | 256 | 64 | >512 | 512 | <0.75 | Synergy or Addition |
| Strain | MIC (µg/mL) for GM in the Presence of: | MIC (µg/mL) for 13-o-MBB in the Presence of: | FIC | Mode of Interaction | ||
| − | 13-o-MBB | − | GM | |||
| PAGUg1931 | 8 | 8 | 256 | 256 | 2.0 | Indifferent |
| PAGUg1927 | 1024 | 32 | 512 | 4 | 0.04 | Synergy |
| PAGUg1659 | 0.5 | 0.5 | >512 | >512 | >1.0 | Indifferent |
| PAGU 1606 | 64 | 2 | >512 | 8 | <0.5 | Synergy |
| Strain | MIC (µg/mL) for GM in the Presence of: | MIC(µg/mL) for Berberine in the Presence of: | FIC | Mode of Interaction | ||
| − | Berberine | − | GM | |||
| PAGUg1931 | 8 | 8 | >512 | >512 | >1.0 | Indifferent |
| PAGUg1927 | 1024 | 128 | >512 | 8 | <0.5 | Synergy |
| PAGUg1659 | 0.5 | 0.5 | >512 | >512 | >1.0 | Indifferent |
| PAGU 1606 | 64 | 8 | >512 | 256 | <0.5 | Synergy |
Note: GM, gentamicin; AMK, amikacin; FIC, fractional inhibitory concentration index.