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. 2019 Dec 30;5(1):179–188. doi: 10.1021/acsomega.9b02344

Figure 2.

Figure 2

Plot showing a direct correlation between intrinsic clearance (log10Clint,u) and log D7.4 values for the particular range of LipMetE for the marketed drugs and model substrates metabolized by CYP450s (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4).