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This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
Plot showing a direct
correlation between intrinsic clearance (log10Clint,u) and log D7.4 values for the
particular range of LipMetE for the marketed
drugs and model substrates metabolized by CYP450s (CYP1A2, CYP2C9,
CYP2C19, CYP2D6, and CYP3A4).