. 2019 Dec 30;5(1):179–188. doi: 10.1021/acsomega.9b02344

Table 1. Table Summarizing the LipMetE, LipE, log D_7.4, and log₁₀CL_int,u Ranges for the CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 Substrate datasets That Were Used for LipMetE Calculations^a.

					known drugs and model substrates data (LipMetE 0–2.5)
CYP450	LipE range	LipMetE range	log D_7.4 range	log₁₀CL_int,u range	no of substrates with LipMetE between 0 and 2.5	LipE range	average LipE	average LipMetE	average log D_7.4	average log₁₀CL_int,u
CYP1A2	–1.96 to 7.24	–4.54 to 4.35	–1.19 to 4.24	–3.08 to 4.72	8	–1.96 to 3.03	0.88	0.94	2.25	1.28
CYP2C9	–1.02 to 5.01	–3.72 to 3.63	–0.98 to 5.92	–0.015 to 5.18	6	–0.83 to 2.73	1.00	0.69	2.63	1.94
CYP2C19	–4.20 to 5.13	–6.40 to 4.70	–1.29 to 5.68	–1.87 to 6.49	3	–2.18 to 0.95	–0.15	0.70	2.73	2.02
CYP2D6	–1.18 to 4.73	–6.35 to 2.93	–2.01 to 5.09	–0.53 to 6.72	11	–1.14 to 2.17	0.50	1.03	2.48	1.46
CYP3A4	–2.36 to 6.66	–6.19 to 3.85	–1.26 to 5.16	–3.08 to 7.27	23	–1.98 to 2.72	0.85	0.75	2.64	1.89

The average values for LipMetE, LipE, log D_7.4, and log₁₀CL_int,u have been derived using drugs and model substrates from each dataset with better metabolic profiles (LipMetE 0–2.5).

Table 1. Table Summarizing the LipMetE, LipE, log D7.4, and log10CLint,u Ranges for the CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 Substrate datasets That Were Used for LipMetE Calculationsa.

Table 1. Table Summarizing the LipMetE, LipE, log D_7.4, and log₁₀CL_int,u Ranges for the CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 Substrate datasets That Were Used for LipMetE Calculations^a.