Table 2. Table Summarizing LipE, ΔG, LE, and c log P Ranges for the CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 Substrate Datasets That Were Used for LipE and LE Profiling^a.

						known drugs and model substrates data
CYP450	no of substrates	LipE range	ΔG range	LE range	c log P range	no of substrates	average LipE	average LE	average c log P
CYP1A2	58	–1.96 to 7.24	–9.09 to −3.48	0.185–1.42	–2.8 to 6.4	35	1.62	0.35	2.68
CYP2C9	55	–1.02 to 5.00	–9.04 to −3.74	0.187–0.75	0.23 to 5.68	39	1.68	0.32	3.06
CYP2C19	60	–4.21 to 5.13	–10.0 to −1.49	0.064–0.50	–0.78 to 5.59	35	1.08	0.29	3.19
CYP2D6	73	–1.18 to 5.14	–11.25 to −2.86	0.12–0.63	–0.04 to 7.41	46	1.57	0.32	3.02
CYP3A4	101	–2.52 to 6.66	–10.45 to −2.26	0.1–1.28	–2.8 to 7.41	75	1.13	0.24	3.23

^aThe average values of LipE, ΔG, LE, and c log P against each CYP isoform were calculated using all marketed drugs and model substrates included in each CYP substrate dataset.