Table 2. Comparison of Mechanical Properties of nHA-Integrated Polymers with Cortical Bone and Their Regenerative Properties^a.

nanocomposite	method of fabrication	physical nature of composite	regenerative indicators	particle distribution	in vivo or in vitro test	physical dimension of nHA	mechanicalstrength	ref
nHA/polyethylene (ultrahigh molecular weight)	melt-extrusion method	pellets	apatite nucleation, cell adhesion and proliferation	yes	in vitro	average particle size: 150 nm	↑	(43)
polylactide/nHA	template-assisted self-assembly	3D	cell viability, cell adhesion and proliferation	yes	in vitro	N/A	↓	(44)
l-lactide/nHA	surface modification and ring-opening polymerization	pellets	N/A	yes	N/A	neddle-like 100–200 nm length; 20–30 nm width	↓	(45)

^aKeys: NA: no data to support theme; ↑ within range of cortical bone mechanical profile; ↓ below range of cortical bone mechanical profile.