Figure 6.

Impact of ivermectin on transmission when there is variation in worm response. (A) Pre-treatment phenotypic (colors) and genetic diversity within a person is high. (B) When a person is treated with ivermectin, microfilariae are cleared from the skin and the uteri of the worms. (C) Post-treatment, some worms begin reproducing earlier than others, giving them a transmission advantage (black phenotype). If this is a heritable trait, then a correlation between the phenotype and genotype arises; in this case, between both the C at position 2 and the G at position 6 in the sequence.