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. 2020 Jan 15;21:25. doi: 10.1186/s12931-020-1275-8

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Azithromycin induces lysosomal accumulation in control and IPF fibroblasts. a Control (A1–3) and IPF fibroblasts (A4–6) were treated with AZT for 24 h, fixed and analyzed by electron microscopy. (A1, 4) Overview, (A2, 5) late endosomes or lysosomes (arrows), (A3, 6) autolysosomes, double membrane (arrows). b Lysotracker green staining in control (upper images, n = 3) and IPF fibroblasts (lower images, n = 3) after 24 h treatment with AZT in presence or absence of TGF-β confirmed the vacuolar structures as lysosomes. Magnification of 63x. Scale bar = 10 μM. All experiments were performed in three independent experiments