Table 1.
Characteristics of the included studies
| Author | Location | Study Period | Staging | Stage (S) | No. of Patients | Margin Positive (%) | Node Positive (%) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| No ART | ART | No ART | ART | No ART | ART | |||||
| Balalchandran et al. [14] | GBC | 1989–2000 | The 5th AJCC | I: 10.3%, II: 13.7%, III: 61.6%, IV: 12.8% | 44 | 73 | NR | NR | 57 | 42 |
| Borghero et al. [15] | EHCC | 1984–2005 | The 6th AJCC | I: 38.4%, II: 61.6% | 23 | 42 | 0 | 64 | 13 | 28.3 |
| Cheng et al. [16] | EHCC | 1997–2002 | The 6th AJCC | I: 30.7%, II: 12%, III: 49.3%, IV: 8% | 34 | 23 | NR | NR | NR | NR |
| Gerhards et al. [17] | EHCC | 1983–1998 | NR | I: 14%, II: 35%, III: 44%, IV: 5% | 20 | 71 | NR | NR | NR | NR |
| Gold et al. [18] | GBC | 1985–2004 | The 6th AJCC |
I: 59%, II: 41% |
48 | 25 | 0 | 0 | 30 | 70 |
| Gu et al. [19] | GBC | 2003–2013 | The 7th AJCC |
II: 48.5%, III: 41.5%, IV: 9.6% |
39 | 39 | 0 | 0 | NR | NR |
| Heron et al. [20] | GBC | 1983–1997 | NR | NR | 13 | 13 | NR | NR | NR | 14 |
| Hughes et al. [21] | EHCC | 1994–2003 | The 6th AJCC |
II: 56%, III: 44% |
27 | 35 | 7 | 26 | 37 | 82 |
| Im et al. [22] | EHCC | 2001–2010 | The 6th AJCC | I: 31.3%, II: 58.9%, III: 9.8% | 168 | 49 | 13.7 | 61.2 | 19.6 | 16.3 |
| Itoh et al. [23] | EHCC | 1994–2004 | NR | I: 36.8%, II: 47.4%, III: 15.8% | 10 | 11 | 25 | 82 | NR | NR |
| Kim et al. [24] | EHCC | 2000–2013 | The 7th AJCC |
I: 32.7%, II: 59.6%, III: 7.7% |
33 | 19 | 30 | 74 | 27 | 42 |
| Liang et al. [25] | GBC | 1991–2006 | The 7th AJCC |
T1–2: 33.3%, T3–4: 66.7% |
38 | 11 | NR | NR | 34.2 | 54.5 |
| Lee et al. [26] | GBC | 1994–2011 | The 7th AJCC |
T1: 24%, T2: 45%, T3: 23%, T4: 19% |
83 | 62 | 11 | 12 | 11 | 19 |
| Lindell et al. [27] | GBC | 1991–1999 | The 5th AJCC |
I: 10%, II: 30%, III: 25%, IV: 35% |
10 | 10 | 50 | 50 | 20 | 30 |
| Meng et al. [28] | EHCC | 1992–1997 | NR | IVa | 19 | 28 | 100 | 100 | 63.2 | 53.5 |
| Pitt et al. [29] | EHCC | 1988–1993 | NR | NR | 17 | 14 | NR | 87 | NR | NR |
| Sagawa et al. [30] | EHCC | 1980–1998 | The 5th AJCC |
I: 20.3%, II: 30.4%, III: 31.9%, IV: 17.4% |
30 | 39 | 56.7 | 46.2 | NR | NR |
| Todoroki et al. [31] | GBC | 1976–1996 | NR | IV: 100% | 19 | 28 | 100 | 100 | NR | NR |
| Todoroki et al. [32] | EHCC | 1976–1999 | AJCC | IVA: 100% | 21 | 42 | 95.2 | 97.2 | NR | NR |
| Wang et al. [33] | GBC | 1985–2008 | The 7th AJCC | T1–2: 58.9%, T3–4: 41.1% | 44 | 68 | 9 | 37 | 18 | 63 |
| Zlotecki et al. [34] | EHCC | 1962–1993 | NR | NR | 13 | 10 | NR | NR | NR | NR |