Table 2.
Comparative analysis between clinical forms.
| Clinical forms |
|||
|---|---|---|---|
| RRMS (n = 20) | SPMS (n = 8) | P | |
| Age (years) | 41 (37–47) | 51 (48–57) | 0.002 |
| Time since diagnosis (years) | 6 (5–10) | 13 (11–18) | 0.004 |
| EDSS | 1 (0–1) | 4.5 (4–6.3) | <0.001 |
| SDMT | 58 (50–64) | 36 (24–43) | <0.001 |
| CBF superior frontal gyrus | 49.4 (39.4–59.2) | 37.8 (29.6–42.8) | 0.033 |
| CBF middle frontal gyrus | 59.5 (42.3–67.1) | 39.7 (29.8–47.7) | 0.01 |
| CBF inferior frontal gyrus | 56.1 (47.3–64.4) | 41 (33.6–53) | 0.025 |
| CBF caudate | 31.8 (28–35.3) | 28.1 (26.7–30.5) | 0.182 |
| CBF thalamus | 39.2 (30.8–46.9) | 31.5 (26–37.1) | 0.028 |
| BAT superior frontal gyrus | 1288.2 (1246.7–1380.1) | 1348.8 (1251.2–1464.5) | 0.328 |
| BAT middle frontal gyrus | 1347.8 (1292.9–1469.3) | 1458.7 (1382.1–1538.9) | 0.182 |
| BAT inferior frontal gyrus | 1185.3 (1149.9–1258) | 1228.1 (1209.6–1327.9) | 0.165 |
| BAT caudate | 1115.1 (1080.5–1192) | 1145.9 (1126.5–1228.4) | 0.136 |
| BAT thalamus | 1210.4 (1164.7–1304.7) | 1298.4 (1251.60–1327.6) | 0.07 |
| CV superior frontal gyrus | 23,003 (2207–25,775) | 22,105 (16,649–24,761) | 0.231 |
| CV middle frontal gyrus | 22,531.5 (21,416.5–23,783.5) | 20,404.5 (17,965.5–23,401.5) | 0.15 |
| CV inferior frontal gyrus | 10,839 (10,277–11,894) | 9902.5 (9198.5–11,123) | 0.079 |
| CV caudate | 3597 (3225–3983.5) | 3315 (3018–3735) | 0.237 |
| CV thalamus | 7669.5 (7097.5–9087.5) | 6313 (6125.5–8391) | 0.079 |
Values are given as median (IQR).
Values in bold represent statistically significant differences.
BAT, bolus arrival time (in ms); CBF, cerebral blood flow (in mL/100g/min); CV, cerebral volume (in mm3); EDSS, Expanded Disability Status Scale; IQR, interquartile range; RRMS, relapsing-remitting multiple sclerosis; SDMT, Symbol Digit Modalities Test; SPMS, secondary progressive multiple sclerosis.