Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 9;9:426. doi: 10.3389/fcimb.2019.00426

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Zúñiga, Aravena, Pulgar, Travisany, Ortiz-Severín, Chávez, Maass, González and Cambiazo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic model of the life cycle of P. salmonis. The pathogen alternates between an intracellular replicative phase (A) and a stationary phase (B). Entry into stationary phase activates the stringent response of P. salmonis (C). It is suggested that amino acid and fatty acid starvation triggers RelA and SpoT to produce the (p)ppGpp. Its accumulation induces the activation of the stress sigma factor RpoS and the LetA/LetS two component system along with a global shutdown of translation, transcription, and replication processes. In addition, several components of the Dot/Icm Type IVB secretion system are induced. PCV: P. salmonis-containing vacuole.