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Model for the initial step of cellular uptake of MPG or MPG/cargo complexes. (1) Binding of MPG or MPG/cargo to the extracellular matrix via the proteoglycan platform; (2) clustering of glycosaminoglycans (GAGs), which in turn activates the Rac1 GTPase; (3) actin network remodeling; (4) increase of membrane fluidity, promoting MPG uptake. Reprinted with permission from [32], copyright 2007 The Royal Society of Chemistry.
