Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 19;121(12):1069–1078. doi: 10.1038/s41416-019-0633-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s), under exclusive licence to Cancer Research UK 2019, corrected publication 2023

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — TRIP13 is required for colony formation and tumorigenesis of GBM cells. a, b Soft agar assay was performed in U87MG and LN229 cells with TRIP13 knocked down as well as TRIP13-rescued TRIP13-knockdown cells. Quantification of the number of cell clones. c, e The size and weight of xenograft tumours were analysed in TRIP13-knockdown and TRIP13-rescued TRIP13-knockdown LN229 cells. d The growth curve of tumours was determined for TRIP13-knockdown and rescue of TRIP13-knockdown LN229 cells that were injected into immunodeficient mice. These data were analysed with a two-tailed Student’s t test, and the P-value is indicated. f, g Immunohistochemical staining was performed to detect the expression of TRIP13, Ki67, c-MYC and FBXW7 in TRIP13-knockdown and rescue of TRIP13-knockdown tumour tissues. All P-values are based on the control versus treatment group