Table 2.
Multivariate analysis for predictors of (a) overall survival; (b) disease-free survival; (c) lymph node metastasis; (d) distant metastasis in FFPE cohort of gastric cancer patients.
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| (a) | ||||||
| Age (>68) | 2.02 | 1.18–3.46 | 0.01* | 1.35 | 0.77–2.36 | 0.3 |
| Gender (male) | 1.33 | 0.72–2.44 | 0.36 | |||
| Histology (diffuse) | 0.9 | 0.52–1.58 | 0.72 | |||
| T classification (T3/4) | 12.4 | 5.3–29.1 | <0.0001* | 1.69 | 0.51–5.63 | 0.39 |
| Venous invasion (present) | 6.53 | 3.29–13 | <0.0001* | 0.96 | 0.43–2.12 | 0.91 |
| Lymphovascular invasion (present) | 28.1 | 3.89–203 | 0.0009* | 4.35 | 0.48–39.3 | 0.19 |
| Nerve invasion (present) | 14.6 | 4.54–46.7 | <0.0001* | 1.42 | 0.29–6.99 | 0.66 |
| Lymph node metastasis (present) | 14.8 | 6.32–34.6 | <0.0001* | 3.87 | 1.5–10 | 0.005* |
| Distant metastasis (present) | 11.2 | 6.46–19.5 | <0.0001* | 3.24 | 1.78–5.9 | 0.0001* |
| L1CAM expression (high) | 6.79 | 3.92–11.8 | <0.0001* | 2.45 | 1.31–4.58 | 0.005* |
| (b) | ||||||
| Age (>68) | 2.21 | 1.23–3.96 | 0.008* | 1.24 | 0.66–2.34 | 0.51 |
| Gender (male) | 1.93 | 0.93–4.02 | 0.08 | |||
| Histology (diffuse) | 1.03 | 0.56–1.88 | 0.93 | |||
| T classification (T3/4) | 29.1 | 9.01–93.9 | <0.0001* | 9.23 | 1.73–49.2 | 0.009* |
| Venous invasion (present) | 5.73 | 2.9–11.3 | <0.0001* | 1.03 | 0.46–2.3 | 0.94 |
| Lymphovascular invasion (present) | 13.7 | 3.32–56.6 | 0.0003* | 1.67 | 0.33–8.5 | 0.33 |
| Nerve invasion (present) | 45.3 | 6.23–328 | 0.0002* | 3.26 | 0.31–34.8 | 0.33 |
| Lymph node metastasis (present) | 13.1 | 5.87–29.5 | <0.0001* | 2.74 | 1.15–6.5 | 0.023* |
| L1CAM expression (high) | 5.5 | 3.05–9.91 | <0.0001* | 2.55 | 1.33–4.87 | 0.047* |
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | |
| (c) | ||||||
| Age (>68) | 1.51 | 0.96–2.38 | 0.08 | |||
| Gender (male) | 2.45 | 1.44–4.17 | 0.001* | 3.12 | 1.57–6.19 | 0.001* |
| Histology (diffuse) | 0.74 | 0.46–1.19 | 0.22 | |||
| T classification (T3/4) | 14 | 8.04–24.3 | <0.0001* | 3.87 | 1.76–8.49 | 0.0007* |
| Venous invasion (present) | 8.52 | 5.08–14.3 | <0.0001* | 1.27 | 0.62–2.58 | 0.51 |
| Lymphovascular invasion (present) | 45.8 | 14–149 | <0.0001* | 16.5 | 4.38–62.4 | <0.0001* |
| Nerve invasion (present) | 14.8 | 7.84–28 | <0.0001* | 1.69 | 0.69–4.18 | 0.25 |
| L1CAM expression (high) | 4.52 | 2.58–7.92 | <0.0001* | 2.18 | 1.03–4.63 | 0.042* |
| (d) | ||||||
| Age (>68) | 1.44 | 0.75–2.78 | 0.28 | |||
| Gender (male) | 1.16 | 0.55–2.43 | 0.69 | |||
| Histology (diffuse) | 0.9 | 0.45–1.8 | 0.76 | |||
| T classification (T3/4) | 32.8 | 7.74–138 | <0.0001* | 9.49 | 1.18–76.4 | 0.035* |
| Venous invasion (present) | 12.1 | 4.6–31.8 | <0.0001* | 3.07 | 1.02–9.21 | 0.046* |
| Lymphovascular invasion (present) | – | – | 0.99 | |||
| Nerve invasion (present) | 18.2 | 4.3–76.9 | 0.0001* | 0.69 | 0.08–5.93 | 0.73 |
| Lymph node metastasis (present) | 13.3 | 5.6–35.1 | <0.0001* | 3.1 | 1.02–9.37 | 0.045* |
| L1CAM expression (high) | 8.84 | 4.32–18.1 | <0.0001* | 3.88 | 1.74–8.65 | 0.0009* |
The median age at surgery is 68 years.
Cut-off threshold of L1CAM was determined by ROC analysis with Youden's index for OS in (a); DFS in (b); lymph node metastasis in (c); and distant metastasis in (d)
HR Hazard ratio, OR Odds ratio
*Bold values indicate p < 0.05