Table 1.

Association of clinicopathological factors, cell nest size, tumour budding activity and Cellular Dissociation Grade with survival parameters in univariate survival analysis

	Overall	Events (OS)	Mean overall survival	p-value	Events (DSS)	Mean disease-specific survival	p-value	Events (DFS)	Mean disease-free survival	p-value
Age
Median and below	59	43	55.2	0.05	37	61.0	0.022	42	52.6	0.45
Above median	63	52	48.0		49	52.8		50	45.2
Sex
Male	95	74	58.8	0.80	65	69.0	0.539	70	59.9	0.399
Female	27	21	41.6		21	41.6		22	32.1
ypT
1	12	8	63.4	0.16	7	69.9	0.199	8	59.4	0.434
2	35	25	56.2		24	58.7		26	50.3
3	71	58	37.6		53	40.2		56	35.4
4	4	4	66.9		2	95.8		2	95.8
ypN
0	75	55	71.8	0.09	48	84.5	0.065	51	73.9	0.041
1	45	38	33.7		36	36.3		39	29.9
2	2	2	26.2		2	26.2		2	19.9
ypM
0	117	91	57.9	0.125	82	66.1	0.094	87	57.8	0.02
1	5	4	14.8		4	14.8		5	12.4
Regression grade (Becker et al.)
1B	51	34	58.0	0.026	29	65.0	0.013	32	56.4	0.012
2	22	16	47.3		16	47.3		17	44.1
3	49	45	40.5		41	46.2		43	38.8
Tumour budding (1 HPF)
None	15	7	77.9	0.025	4	96.1	0.003	5	83.9	0.001
Low (2–4 buds)	49	42	52.9		37	62.5		49	55.7
High ( ≥5 buds)	58	46	39.3		45	40.6		58	33.9
Cell nest size
>15 cells	11	5	77.7	0.085	3	95.4	0.010	3	95.7	0.01
5–15 cells	4	2	74.5		1	95.9		2	67.2
2–4 cells	19	15	59.6		12	64.7		13	54.3
Single cells	88	73	50.8		70	53.4		74	45.3
Cellular Dissociation Grade
CDG-G1 (score 2–3)	15	7	77.9	0.038	4	96.1	0.004	5	83.9	0.003
CDG-G2 (score 4–5)	19	16	57.7		13	62.3		14	52.3
CDG-G3 (score 6–7)	88	72	51.0		69	53.6		73	45.5

Italics values indicate statistical significance p-values