Table 2.
Algorithm to determine the Cellular Dissociation Grade derived from tumour budding activity (1–3 points) and cell nest size (1–4 points) in ESCC after neoadjuvant treatment
| Cellular Dissociation Grade for oesophageal squamous cell carcinoma after neoadjuvant treatment | |
|---|---|
| Tumour budding activity/1 HPF | |
| No budding | 1 |
| <5 budding foci | 2 |
| ≥5 budding foci | 3 |
| Smallest cell nest size | |
| >15 cells | 1 |
| 5–15 cells | 2 |
| 2–4 cells | 3 |
| Single-cell invasion | 4 |
| Cellular Dissociation Grade | Total score |
| Well differentiated (CDG-G1) | 2–3 |
| Moderately differentiated (CDG-G2) | 4–5 |
| Poorly differentiated (CDG-G3) | 6–7 |