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. 2020 Jan 9;10:2963. doi: 10.3389/fimmu.2019.02963

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Copyright © 2020 Kiripolsky, Romano, Kasperek, Yu and Kramer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TLR-related genes are dysregulated in splenic tissue derived from NOD.B10 mice. Spleens were harvested from NOD.B10 females with clinical disease (n = 3) and age and sex-matched BL/10 controls (n = 3) and RNA-sequencing was performed. Bargraph showing the KEGG pathway terms represented in the top 1000 genes enriched in NOD.B10 mice. Dotted line represent the boundary for p = 0.05 (A). Heatmap visualizations showing the relative expression levels of selected DEGs involved in TLR-related signaling pathways (B) and cytokines and chemokines (C) that were enriched in NOD.B10 splenic tissue.