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. 2020 Jan 9;10:2963. doi: 10.3389/fimmu.2019.02963

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Copyright © 2020 Kiripolsky, Romano, Kasperek, Yu and Kramer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NOD.B10 SMG tissue exhibits spontaneous secretion of pro-inflammatory mediators that are enhanced in the presence of LPS. NOD.B10 female mice with clinical disease (n = 5) were euthanized and SMG tissue harvested and pooled. Cells were cultured in the presence or absence of LPS for 24 h and the supernatant harvested. (A) IL-6, (B) IL-17, (C) TNFα, (D) MCP-1, and (E) RANTES were assessed by cytokine multiplex array. All samples were analyzed in triplicate and results from one of three independent experiments are shown. Significance was determined using Mann–Whitney test. SEM is shown (^*p ≤ 0.05, ^**p ≤ 0.01, ^***p ≤ 0.001, ^****p ≤ 0.0001, N.S., non-significant).