Table 1.
Overview of renal expression, function, and associated disorders of TRPCs.
| TRPCs | Location of expression in kidney | Role in kidney | Kidney diseases or injuries associated with TRPC disorders | Objects of research | References |
|---|---|---|---|---|---|
| TRPC1 | MC; PTEC; TAL | Regulation of mesangial cell contractility; regulation of Ca2+ influx | Diabetic nephropathy | Human; ZDF rats; STZ-induced rats; Ang II-induced human MC | [12, 13] |
| TRPC2 | A pseudogene and does not form functional channels in human | [14] | |||
| TRPC3 | P; CDEC; RF | Regulation of Ca2+ influx | Autosomal dominant polycystic kidney disease; renal interstitial fibrosis | TRPC3−/− mice; UUO rats; CiPTEC cells with siTRPC3; IMCD3 cells treated with pcDNA/TRPC3; RF treated by the pyrazole-derivative TRPC3 blocker pyr3 | [15, 16] |
| TRPC4 | MC | Store-operated Ca2+ entry | Unknown | Mouse MC line (CRL-1927) under high-glucose conditions | [17] |
| TRPC5 | P | Regulation of Ca2+ influx; regulation of actin cytoskeleton rearrangement (need to be further investigated) | Progressive kidney diseases Focal segmental glomerulosclerosis |
TRPC5-KO mice by LPS injection; mouse podocytes treated by PS, LPS, and Cch | [18, 19] |
| TRPC6 | P; MC EC; CDEC |
Regulation of Ca2+ influx; regulation of actin cytoskeleton rearrangement | Focal segmental glomerulosclerosis; minimal change disease; membranous glomerulonephritis; type-1 diabetes; renal fibrosis | Human; PHN rats; C5b-9-attacked podocytes; HEK293 cells recombined with mouse GFP-TRPC6 | [20, 21] |
| TRPC7 | Unknown | ||||
Abbreviations: MC: mesangial cell; PTEC: proximal tubule epithelial cells; TAL: thick ascending limb of the loop of Henle; P: podocytes; CDEC: collecting duct epithelial cells; RF: renal fibroblasts; EC: endothelial cells; ZDF: Zucker diabetic fatty; STZ: streptozotocin; Ang II: angiotensin II; CiPTEC: human conditionally immortalized proximal tubular epithelial cells; IMCD3: mouse inner medullary collecting duct cell line; UUO: unilateral ureteral obstruction; LPS: lipopolysaccharide; PS: protamine sulfate; Cch: carbachol; PHN: the passive Heymann nephritis (PHN) model; HEK: human embryonic kidney.