Table 6.
ROC analysis of antioxidant defence, total antioxidant/oxidant status, and markers of oxidative damage to proteins and lipids in erythrocytes and plasma of psoriasis patients compared to the controls.
| Parameter | ||||||
|---|---|---|---|---|---|---|
| AUC | 95% confidence interval | p value | Cut-off | Sensitivity | Specificity | |
| Erythrocytes | ||||||
| GPx (mU/mg protein) | 0.73 | 0.609 to 0.8472 | 0.0004 | >0.55 | 65.00 | 65.00 |
| CAT (nmol H2O2/min/mg protein) | 0.85 | 0.7564 to 0.9336 | <0.0001 | >0.63 | 80.00 | 80.00 |
| SOD (mU/mg protein) | 0.51 | 0.3811 to 0.6414 | 0.8625 | <6.29 | 57.00 | 57.00 |
| Plasma | ||||||
| GSH (μg/mg protein) | 0.82 | 0.7205 to 0.9108 | <0.0001 | <2.21 | 75.00 | 75.00 |
| TAC (Trolox μmol/mg protein) | 0.5 | 0.3618 to 0.6457 | 0.954 | <3.56 | 52.50 | 52.50 |
| OSI (TOS/TAC ratio) | 0.96 | 0.916 to 0.9953 | <0.0001 | >8.81 | 85.00 | 85.00 |
| AGE (AFU/mg protein) | 0.92 | 0.8492 to 0.9895 | <0.0001 | >1.68 | 87.5 | 87.5 |
| AOPP (nmol/mg protein) | 0.77 | 0.6554 to 0.8746 | <0.0001 | >7.73 | 70.00 | 70.00 |
| MDA (μmol/mg protein) | 1.00 | 1 to 1 | <0.0001 | >264.00 | 100.00 | 100.00 |
| LOOH (nmol/mg protein) | 0.96 | 0.9091 to 1.013 | <0.0001 | >0.36 | 95.00 | 95.00 |
Abbreviations: AGE: advanced glycation end products; AOPP: advanced oxidation protein products; AUC: area under curve; CAT: catalase; GSH: reduced glutathione; GPx: glutathione peroxidase; LOOH: total lipid hydroperoxides; MDA: malondialdehyde; OSI: oxidative stress index; SOD: superoxide dismutase; TAC: total antioxidant capacity.