TABLE 2.
Inhibition spectra of purified peptides of nisins A, Z, and J against indicator strains using well diffusion assays and expressed as the area of the zone of inhibition
| Target microorganism | Strain | Area of zone of inhibitiona (mm2) for nisin: |
||
|---|---|---|---|---|
| A | Z | J | ||
| Corynebacterium xerosis | DPC 5629 | 51.5 | 66.2 | 133.8 |
| Cutibacterium acnes | LMG 16711 | 537 | 587.5 | 469 |
| Lactobacillus delbrueckii subsp. bulgaricus | LMG 6901 | 555.7 | 672.7 | 651.44 |
| Lactococcus lactis subsp. cremoris | HP | 241.9 | 325.8 | 363 |
| Listeria monocytogenes | WSLC 112 | 60 | 73 | 37 |
| Enterococcus faecium | APC 852 | 93.2 | 120.6 | 170.9 |
| Enterococcus faecalis | ATCC 19433 | 101.2 | 120.8 | 102.97 |
| Methicillin-resistant Staphylococcus aureus | DPC 5645 | 77 | 115.9 | 135.8 |
| Staphylococcus aureus | DPC 7016 | 109.4 | 143.4 | 153.1 |
| Staphylococcus epidermidis | DPC 5990 | 136.8 | 180.3 | 159.5 |
| Staphylococcus simulans | APC 3482 | 148.7 | 197.1 | 395.5 |
| Streptococcus agalactiae | ATCC 13813 | 174.4 | 221.7 | 136.8 |
| Streptococcus uberis | DPC 5344 | 98.5 | 153.9 | 248.8 |
a
Calculated as the area of zone of inhibition (πr2) − area of well (πr2) in millimeters. Assays were carried out in duplicate; mean zone areas shown.