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. 2019 Dec 20;37(2):382–388. doi: 10.1089/neu.2019.6711

FIG. 1.

FIG. 1.

Neuron-derived exosome (NDE) levels of normal functional cargo proteins in cross-sectional control, cognitive impairment (CI) with no history of traumatic brain injury (TBI), TBI without (w/o) CI, and TBI with (w) CI groups. Each point represents the value for one participant, and the horizontal line in point clusters is the mean level for that group. Mean ± standard error of the mean for control w/o TBI, CI w/o TBI, TBI w/o CI, and TBI w CI, respectively, are 1711 ± 101 pg/mL, 1474 ± 154 pg/mL, 1595 ± 139 pg/mL, and 1505 ± 145 pg/mL for claudin-5 (A), 47256 ± 3249 pg/mL, 45274 ± 3882 pg/mL, 35831 ± 3503 pg/mL, and 47087 ± 3486 pg/mL for annexin VII (B), 4787 ± 397 pg/mL, 3029 ± 251 pg/mL, 3623 ± 408 pg/mL, and 3522 ± 241 pg/mL for aquaporin 4 (C), 7986 ± 922 pg/mL, 17149 ± 1207 pg/mL, 6949 ± 702 pg/mL, and 17730 ± 995 pg/mL for PrPc (D), and 81.7 ± 11.0 pg/mL, 145 ± 19.7 pg/mL, 64.3 ± 9.14 pg/mL, and 142 ± 13.3 pg/mL for synaptogyrin-3 (E). The significance of differences shown between values for controls and CI w/o TBI subjects and between values for TBI w/o CI and TBI with CI subjects, respectively, were calculated by an unpaired Student t test; *p < 0.01, **p < 0.001.