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. 2020 Jan 6;18(1):e3000596. doi: 10.1371/journal.pbio.3000596

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© 2020 Grasselli et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — (A) LTD is induced at comparable levels at PF synapses in SK2-KO PCs and WT littermates (induction protocol: 1-Hz paired PF + CF single pulse, 5 min). Upper panel: representative traces of PF-EPSCs. Lower panel: time graph of PF-EPSCs (averaged per minute) before and after the induction (at 0 min). (B) LTP is induced at comparable levels at PF synapses in SK2-KO PCs and WT littermates (induction protocol: 1-Hz PF single pulse, 5 min). Upper panel: representative traces of PF-EPSCs. Lower panel: time graph of PF-EPSCs as in A. (C) Intrinsic plasticity cannot be induced in SK2-KO PCs by a somatic depolarization protocol (this panel is reproduced in a modified form from [44]). Upper panel: representative traces of spikes evoked by a somatic depolarizing current injection of fixed amplitude, before (upper) and after (lower) the induction protocol. Lower panel: time graph of spike count (averaged per minute) before and after the induction (at 0 min). **p < 0.01. CF, climbing fiber; EPSC, excitatory postsynaptic current; KO, knockout; LTD, long-term synaptic depression; PC, Purkinje cell; PF, parallel fiber; WT, wild type.