FIG 5.

H19 knockdown suppressed the expression of proliferation-associated gene by inhibiting miR-152-3p-mediated BRD4 signaling pathway. (A) The expression of BRD4, c-Myc, survivin, cyclin D1, CDK4, Bax, and Bcl-2 was detected by Western blotting in MM1.R and RPMI-8226 cells transfected with sh-H19, miR-152-3p mimics, or miR-152-3p inhibitor. (B) Quantitative analysis of Western blotting. The levels of their expression were normalized to that of GAPDH. All data are representative of 3 independent experiments. *, P < 0.05; **, P < 0.01.