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. 2020 Jan 10;10:1312. doi: 10.3389/fneur.2019.01312

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Copyright © 2020 Fan, Mao, Hu, Zhang, Yang, Hu, Sun, Fan, Dong, Yang, Shi and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathways regulating growth hormone secretagogue receptor 1α (GHSR1α)/dopamine receptor D1 (DRD1) interaction by amyloid beta (Aβ) in the hippocampus of patients with Alzheimer's disease (AD). Aβ binds directly to GHSR1α and inhibits the activation of GHSR1α and prevented GHSR1α/DRD1 heterodimerization, resulting in synaptic plasticity damage and memory loss. In a mouse model of AD, simultaneous use of the selective GHSR1α agonist MK0677 and the selective DRD1 agonist SKF81297 rescued GHSR1α function from Aβ inhibition, thereby reducing hippocampal synaptic damage and improving spatial memory.