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. 2020 Jan 10;10:2991. doi: 10.3389/fimmu.2019.02991

Figure 5.

Figure 5

Design and function of Tregs engineered to express FVIII-specific TCRs, CARs or BARs. (A) The FVIII-TCR Tregs will recognize FVIII peptides with specific HLA-restricted T-cell epitopes. The FVIII-specific scFv Tregs will recognize FVIII domains, with no HLA restriction. The FVIII-BAR T cells will recognize B cells expressing FVIII-specific BCRs. FVIII-BAR Tregs are expected to down-regulate or prevent FVIII-specific B-cell activation, while FVIII-BAR CD8+ T cells should specifically kill only the FVIII-specific B cells. (B) Cartoon showing possible mechanisms by which engineered FVIII-specific Tregs may exert bystander suppression, i.e., create a tolerogenic environment that will suppress nearby T-effectors having specificity for multiple epitopes in FVIII.