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. 2020 Jan 16;10:439. doi: 10.1038/s41598-019-57360-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of key proteins contributing to the effects of FM on cell migration. (a) Protein-protein interaction (PPI) network derived from reverse target screening. The PPI network comprises 1254 nodes and 1463 edges, with pink nodes representing the 15 human seed proteins. (b) Gene Ontology (GO) analysis was conducted on the PPI network to enrich nodes based on their “biological processes” annotation. The structure of cell motility-relevant GO and root terms are depicted. The color of the GO term represents the p-value and size signifies the number of enriched proteins.