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. 2020 Jan 16;10:475. doi: 10.1038/s41598-019-57106-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Colonic and whole gut permeability in vivo comparing young adults vs. elderly. (A) 5–24 urinary sucralose/erythritol ratio in healthy individuals. (B) 5–24 urinary sucralose/erythritol ratio in IBS patients. (C) 0–24 urinary sucralose/erythritol ratio in healthy individuals. (D) 0–24 urinary sucralose/erythritol ratio in IBS patients. Values are presented in scatter plots with median line and IQR (25–75th interquartile range). Urinary sugar ratios were compared between age groups with the use of Mann-Whitney U-tests.