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. 2020 Jan 16;5:2. doi: 10.1038/s41525-019-0108-5

Fig. 7. Mesenchymal and proneural GSCs present lncRNAs differentially expressed, harboring alternative splicing events, and associated with prognosis in GBM patients.

Fig. 7

a Number of lncRNAs presenting alternative splicing events or differentially expressed (left side) and their intersections (right side) in MES or PN GSCs. b Differentially expressed lncRNAs in GSCs with prognostic value to GBM and other cancer patients (“TCGA tumors” follows TCGA nomenclature for cancer types (e.g., LGG low grade glioma)). PO Proto-oncogenes; TSG tumor-suppressor genes. c Survival curves based on median expression values of lncRNAs in GBM patients. Corresponding log-rank p-values and multivariate Cox p-values are also shown. d Representation of lncRNA GAS5 and its retained introns (in red) in MES GSC. Retained introns host three small nucleolar RNAs: SNORD79, SNORD80, and SNORD57.