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. 2020 Jan 16;11(1):34. doi: 10.1038/s41419-019-2188-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Tumor volume from different treatment groups was measured after injection. b Tumor weight from different treatment groups was measured after the mice were euthanized. c–e The expression levels of several genes related with the present study from each group of xenograft were evaluated using qRT-PCR, ELISA and WB. f Representative images of HE-stained mouse lung tissues were taken to demonstrate lung metastasis of HCC xenograft. The amount of metastatic nodules from each group was calculated and analyzed accordingly. All data are presented as the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01.