Table 2.
Mcl-1 expression and apoptosis rate in Mcl-1 inhibitors-treated mouse peritoneal macrophages infected with XJ-MTB
| Groups (n = 10) | Mcl-1 expression | Positive rate (%) | Apoptosis rate (%) | |||
|---|---|---|---|---|---|---|
|
| ||||||
| - | + | ++ | +++ | |||
| Control | 10 | 0 | 0 | 0 | 0 | 0.03 ± 0.01b,c,d,e,f |
| Mcl-1-shRNA | 9 | 1 | 0 | 0 | 10 | 0.44 ± 0.06a,c,d,e,f |
| BCG+Mcl-1-shRNA | 6 | 1 | 2 | 1 | 40 | 3.37 ± 0.03a,b,d,e,f |
| H37Ra+Mcl-1-shRNA | 7 | 1 | 2 | 0 | 30 | 3.7 ± 0.03a,b,c,e,f |
| H37Rv+Mcl-1-shRNA | 9 | 1 | 0 | 0 | 10 | 5.2 ± 0.02a,b,c,d |
| XJ-MTB+Mcl-1-shRNA | 9 | 1 | 0 | 0 | 10 | 5.31 ± 0.03a,b,c,d |
a
P<0.05 vs. control group.
b
P<0.05 vs. Mcl-1-shRNA.
c
P<0.05 vs. BCG+Mcl-1-shRNA.
d
P<0.05 vs. H37Ra+Mcl-1-shRNA.
e
P<0.05 vs. H37Rv+Mcl-1-shRNA.
f
P<0.05 vs. XJ-MTB+Mcl-1-shRNA.