Upregulated renal chemerin and chemR23 expression in the STZ-induced diabetic rats. A. Immunohistochemical staining of chemerin in the rats at 4 and 12 weeks (magnification, ×400); B. Immunohistochemical staining of chemR23 in the rats at 4 and 12 weeks (magnification, ×400); C, D. Western blot analysis of chemerin and chemR23 protein levels in renal tissue of age-matched control rats and diabetic rats at 1, 4 and 12 weeks post-STZ injection. E. qRT-PCR analysis of chemerin and ChemR23 mRNA expression in the renal tissue of age-matched control rats and diabetic rats at 1, 4 and 12 weeks post-STZ injection. **P < 0.001 versus 4 weeks control; ##P < 0.001 versus 12 weeks control.