Table 3.
Allele distributions of TERT variants and their relationships with HCC susceptibility
| SNPs | Chromosome | Position | Allele | Minor allele frequency | HWE P value | OR (95% CI) | P | |
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Case | Control | |||||||
| rs10069690 | 5p15.33 | 1279790 | T/C | 0.135 | 0.171 | 0.6551 | 0.75 (0.59-0.96) | 0.021* |
| rs2242652 | 5p15.33 | 1280028 | A/G | 0.133 | 0.179 | 0.3914 | 0.70 (0.55-0.90) | 0.004* |
| rs2853677 | 5p15.33 | 1287194 | G/A | 0.370 | 0.369 | 0.7174 | 1.00 (0.84-1.20) | 0.966 |
| rs2853676 | 5p15.33 | 1288547 | T/C | 0.132 | 0.159 | 0.8744 | 0.81 (0.63-1.04) | 0.093 |
SNPs: single-nucleotide polymorphisms; HWE: Hardy-Weinberg equilibrium; OR: odds ratio; 95% CI: 95% confidence interval. P values were calculated from Chi-square test/Fisher’s exact test.
*
P ≤ 0.05 indicates statistical significance.