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. 2020 Jan 16;10:474. doi: 10.1038/s41598-019-57173-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Leukocytes play a role in elevation of in-circuit pressure. (A) Whole blood or PRP stored for 7 days was administered to the circuit and then 5 U/mL of unfractionated heparin was administered at 15 minutes. In-circuit pressure was monitored for 60 minutes. N = 6 per group. (B) The paired t-test was used to analyze the difference in the area under the curve (AUC) between whole blood and PRP. N = 6 per group. *p < 0.05. (C) Relative numbers of erythrocytes (RBC), leukocytes (WBC), and platelets (PLT) to the initial numbers in whole blood are shown. N = 3 per group. (D) The filter was removed at 60 minutes and analyzed by immunofluorescence. Fibrin(ogen) was labeled in red and DNA was labeled in blue. Representative images of the whole filter (scale bars: 10 mm) and the magnified view (scale bars: 50 μm) are shown.