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. 2020 Jan 10;10:1533. doi: 10.3389/fphar.2019.01533

Figure 2.

Figure 2

Compound 15c inhibited the phosphorylation of EGFR and FGFR1 in the cell system. (A–D) Representative immunoblots of phosphorylated FGFR1/EGFR, total FGFR1/EGFR, and GAPDH (sample loading controls) in three different cell lines that treated with inhibitors (n = 3 independent experiments for each panel). (A) Analysis of the p-FGFR1 level in bFGF-stimulated H520 cells. (B) Analysis of the p-EGFR level in EGF-stimulated PC9 cells. (C) Analysis of the p-EGFR level in EGF-stimulated H1975 cells. (D) Analysis of the p-FGFR1 level in bFGF-stimulated H1975 cells. The statistical results were shown as means ± SD (n = 3) on the right of each panels. Significant difference was indicated as * or # character (*p < 0.05, **p < 0.01, and ***p < 0.001 versus vehicle group, #p < 0.05, ##p < 0.01, and ###p < 0.001 versus control group).