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Increased loading of an antibiotic in anionic liposomes.
| Liposome type | Zeta potential (mV) | Tobramycin concentration (a.u.) |
|---|---|---|
| DPPC/Chol | −0.5 | 100 |
| DOPC/DPPG | −22.3 | 800 |
Tobramycin-loading in anionic liposomes is eight times higher than in natural neutral liposomes due to the electrostatic interaction between negatively charged lipids and tobramycin. Data taken from Messiaen et al. (2013).
