Table 3.

Minimal inhibitory concentrations of different bacterial strains against antibiotic-loaded liposomes.

Strain	MIC against free antibiotics (mg/L)	MIC against liposomal encapsulated antibiotics (mg/L)	References
Vancomycin
E. coli	512	6–25	Nicolosi et al., 2010
	512	10.5
Klebsiella	512	25–50
P. aeruginosa	512	50
	512	83.7
Acinetobacter baumanii	512	6–125
S. aureus (MRSA)	1	0.5	Bhise et al., 2018
Amikacin
P. aeruginosa	8	4	Mugabe et al., 2006
	16	4
	252	8
	4	2
	512	8
B. cenocepacia	256	8	Halwani et al., 2007
	256	32
	128	16
	>512	8
	4	1
Gentamicin
P. aeruginosa	4	2	Mugabe et al., 2006
	16	2
	32	4
	32	0.5
	256	8
B. cenocepacia	>512	32	Halwani et al., 2007
	256	64
	256	16
	>512	32
	1	0.25
Tobramycin
P. aeruginosa	2	1	Mugabe et al., 2006
	4	4
	64	2
	1	0.5
	1024	8
B. cenocepacia	512	8	Halwani et al., 2007
	>512	64
	128	16
	>512	16
	1	0.25
Piperacillin
S. aureus	64	32	Nacucchio et al., 1985
Cefepime
P. aeruginosa	8	4	Torres et al., 2012
Ceftazidime
P. aeruginosa	8	4	Torres et al., 2012
Levofloxacin
P. aeruginosa	0.5	0.5	Derbali et al., 2019
Voriconazole
Aspergillus sp.	0.5	0.5	Veloso et al., 2018
	0.25	0.25
	0.5	0.25
	1	0.5
Candida sp.	0.03	0.03
	0.06	0.06
	0.03	0.03
	0.03	0.03
Meropenem
P. aeruginosa	125	1.5	Zahra et al., 2017
	62.5	6.25
	62.5	6.25
	125	50
	250	100
	25	6.25
	250	100
	62.5	6.25
	250	50
Clarithromycin
S. aureus ATCC29213	0.25	0.25	Meng et al., 2016
S. aureus MRSA	64	16
P. aeruginosa	>256	8–64	Alhajlan et al., 2013
	256	8–64
	256	8–64
	256	8–6,432; 64; 8
	>256	8–64
	>256	8–64
	>256	8–64
	>256	8–64
	256	8–64
Azithromycin
P. aeruginosa	128	16	Solleti et al., 2015
	64	8
	512	32
	128	16
	256	32
	512	32
	512	128
	256	32
	512	64
	256	16

Multiple MIC values for the same strain, antibiotic and reference, refer to different isolates of the same strain or different liposomes in the same reference.