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. 2020 Jan 10;10:1531. doi: 10.3389/fphar.2019.01531

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Copyright © 2020 He, Wang, Qiao, Zhou, Li, Chen, Yin, Huang and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes of tissues injury, histopathological, and apoptosis in Dox-treated. (A and B) Activities of mice’s serum lactate dehydrogenase (LDH) and creatine kinase (CK). Data are presented as the mean ± S.E.M. for fifteen individual experiments. a: P < 0.01, vs. the control group; b: P < 0.01, vs. the Dox group. (C) hematoxylin-eosin (H&E) staining was performed for morphological analysis in the thoracic aortas tissue. Blue arrow: spotty necrosis; Orange arrow: hypertrophy of interstitial cells. (D) TUNEL staining was performed for morphological analysis in the thoracic aortas tissue. Orange arrow: TUNEL-positive cells.