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. 2020 Jan 10;10:1531. doi: 10.3389/fphar.2019.01531

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Copyright © 2020 He, Wang, Qiao, Zhou, Li, Chen, Yin, Huang and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes of vascular responsiveness, eNOS/NO in serum, and aortic tissue homogenate in Dox-treated. (A) Endothelium-dependent dilation (EDD) of thoracic aortic strips. (B) Area under of the curve for EDD. (C) Endothelium-independent dilation (EID) of thoracic aortic strips. (D) Area under of the curve for EID. (E) Serum contents of NO. (F) eNOS expression in aortic tissue. (G) p-eNOS expression in aortic tissue. On (F and G), from left to right, lane 1: control; lane 2: Dox; lane 3: Eda+Dox; lane 4: pAD/eNOS+Dox. Data are presented as the mean ± S.E.M. for fifteen individual experiments. a: P < 0.01, vs. the control group; b: P < 0.01, vs. the Dox group; c: P < 0.01, vs. the Eda+Dox group.