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. 2020 Jan 10;10:1536. doi: 10.3389/fphar.2019.01536

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Copyright © 2020 Zhu, Lu, Jiang, Yao, Jiang, Huang, Jiang, Peng, Fu and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Islet morphology. (A) Hematoxylin and eosin (H&E), islets conserved their morphology and integrity on post-transplantation day 30. (B) Insulin immunofluorescence, islets secrete insulin after transplantation, particularly 1 mg RHC and 16 mg–60 ng RHC-bFGF groups. (C) Masson's trichrome staining of explanted islet grafts on post-transplantation day 30. Masson's trichrome staining showed collagen expression around the transplantation site on day 30 post-transplantation. (D) Representative immunohistochemical staining of caspase-3 on post-transplantation day 30. a: FREE group; b: 60 ng bFGF group; c: 1 mg RHC group; d: 16 mg RHC group; e: 1 mg–60 ng RHC-bFGF group; f: 16 mg–60 ng RHC-bFGF group.