TABLE 2.
Extent (k) | Peak T-value | Peak p-value |
MNI coordinates (mm) |
|||
x | y | z | ||||
Instant Decrease, During-HDBR + CO2 Recovery | ||||||
Frontal | ||||||
R Middle Frontal Gyrusa | 21 | −3.953 | 1.238 × 10–4 | 48 | 46 | 20 |
L Middle Frontal Gyrus | 15 | −3.617 | 3.517 × 10–4 | −30 | 26 | 44 |
Parietal | ||||||
R Supramarginal Gyrus | 12 | −3.999 | 1.071 × 10–4 | 58 | −30 | 54 |
R Supramarginal Gyrusa | 59 | −3.835 | 1.798 × 10–4 | 52 | −36 | 38 |
Temporal | ||||||
R Inferior Temporal Gyrusa,b | 46 | −4.271 | 4.463 × 10–5 | 60 | −48 | −16 |
Instant Increase, Post-HDBR + CO2 Recovery | ||||||
Frontal | ||||||
R Superior Medial Gyrusb | 15 | 3.781 | 2.123 × 10–4 | 6 | 50 | 50 |
Anterior Cerebellum | ||||||
R Cerebellar Lobule VIb | 9 | 4.093 | 7.938 × 10–5 | 22 | −76 | −21 |
Instant Decrease, Post-HDBR + CO2 Recovery | ||||||
Subcortical | ||||||
Brainstemb | 15 | −3.645 | 3.229 × 10–4 | −4 | −16 | −16 |
Clusters that emerged as significant were the same for the “instant, slow recovery” and “cumulative, slow recovery” increase and decrease contrasts. Thus here we report only the statistics for the instant increase and decrease contrasts. Significance level set at p < 0.001 and cluster size k = 10 for whole brain analyses and cluster size k = 5 for cerebellar analyses. Table includes all local maxima separated by more than 20 mm. Whole-brain results are listed first, followed by cerebellar results. Cortical regions were labeled using the AnatomyToolbox atlas via the SPM toolbox BSPMview. Cerebellar regions were labeled using the SUIT atlas. aPortions of three “instant decrease, during HDBR + CO2 recovery” clusters survived p < 0.0005 and k = 10 thresholding:
(1) R Inferior Temporal Gyrus: k = 24
(2) R Middle Frontal Gyrus: k = 12
(3) R Supramarginal Gyrus: k = 59
bWhole brain and cerebellar clusters with largest T value for each contrast; contrast values are plotted for the peak coordinate within each of these four clusters in Figure 4.