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. 2019 Nov 22;22:105–118. doi: 10.1016/j.jare.2019.11.009

Fig. 10.

Fig. 10

Effect of SB-431542 (TGFβ inhibitor) on cell morphology and replication after exposure to chronic heat shock. (A–C) cells cultured without SB-431542 (SB) supplementation, while (D–F) show cells cultured with SB-431542. (A and D) show cells before heat treatment. (B and E) show the cells after exposure to 45 °C for 20 h. (B) Cells have a rounded enlarged morphology with enlarged nuclei (black arrows), while in (E) cells maintained their spindle morphology (black arrow) degenerated cells were present (white arrow). (C and F) cells regained spindle morphology and replication 120 h post-washing (PW) and medium replacement without SB-431542 and recovery at 38 °C. Scale bar = 100 µm.