Table 3.
Absolute values of lung function indexes in healthy term controls, premature infants without bronchopulmonary dysplasia (BPD), and premature infants with BPD at different corrected ages.
| Control | Premature without BPD | Premature with BPD | ||
|---|---|---|---|---|
| Vt (ml) | 6 mo |
64.74 ± 8.35 (n = 86) |
60.47 ± 11.62* (n = 39) |
58.41 ± 9.33*** (n = 53) |
| 12 mo |
88.23 ± 13.67 (n = 44) |
88.46 ± 11.5 (n = 37) |
74.09 ± 11.17*** (n = 38) |
|
| 18 mo |
107.4 ± 14.6 (n = 20) |
102.7 ± 13.9 (n = 30) |
95.0 ± 14.8 (n = 28) |
|
| 24 mo |
114.5 ± 8.3 (n = 10) |
117 ± 14 (n = 16) |
97.9 ± 22 (=21) |
|
| Rrs (kPa*s/L) | 6 mo |
4.31 ± 1.31 (n = 86) |
4.65 ± 1.48 (n = 37) |
5.43 ± 1.54*** (n = 45) |
| 12 mo |
3.24 ± 0.93 (n = 42) |
3.24 ± 0.82 (n = 30) |
4.06 ± 1.73** (n = 35) |
|
| 18 mo |
2.53 ± 0.45 (n = 19) |
3.22 ± 1.05* (n = 24) |
4.34 ± 2.56** (n = 26) |
|
| 24 mo |
2.1 ± 0.9 (n = 10) |
2.217 ± 0.39 (n = 14) |
3.182 ± 1.29* (n = 20) |
|
| Crs (ml/kPa) | 6 mo |
102.7 ± 29.9 (n = 86) |
84.5 ± 18.4*** (n = 37) |
75.2 ± 23.3*** (n = 45) |
| 12 mo |
140.9 ± 34.6 (n = 42) |
122.4 ± 42.2* (n = 30) |
101.1 ± 19.62*** (n = 35) |
|
| 18 mo |
155.2 ± 25.4 (n = 19) |
150.3 ± 25.5 (n = 24) |
136.7 ± 30.2* (n = 26) |
|
| 24 mo |
180 ± 33 (n = 10) |
188 ± 41 (n = 14) |
129.4 ± 50** (n = 20) |
|
| V’maxFRC (ml/s) | 6 mo |
202.9 ± 98.3 (n = 97) |
112.8 ± 54.2*** (n = 32) |
101.7 ± 52.1*** (n = 46) |
| 12 mo |
282.5 ± 117.2 (n = 68) |
227.4 ± 88.8* (n = 33) |
150.4 ± 65.6*** (n = 37) |
|
| 18 mo |
354.7 ± 134.1 (n = 33) |
291.7 ± 110.8* (n = 29) |
203.5 ± 102.9*** (n = 26) |
|
| 24 mo |
360.1 ± 135.2 (n = 27) |
399.6 ± 136.7 (n = 14) |
220.2 ± 138.1** (n = 20) |
|
| FEV0.5 (ml) | 6 mo |
235 ± 19 (n = 33) |
209.5 ± 29** (n = 10) |
198.7 ± 31.2*** (n = 25) |
| 12 mo |
295.8 ± 17.2 (n = 25) |
302.0 ± 25.1 (n = 8) |
242.2 ± 50.1*** (n = 20) |
|
| 18 mo |
327.6 ± 19.9 (n = 25) |
322.7 ± 33.0 (n = 12) |
294.3 ± 57.7** (n = 22) |
|
| 24 mo |
368 ± 26.5 (n = 14) |
363.3 ± 46.1 (n = 10) |
282.7 ± 56.4*** (n = 16) |
|
| FVC (ml) | 6 mo |
308.8 ± 39.2 (n = 33) |
285.2 ± 49.2 (n = 10) |
273.8 ± 55.7** (n = 25) |
| 12 mo |
436.4 ± 36.0 (n = 25) |
469 ± 42 (n = 8) |
355 ± 63.8*** (n = 20) |
|
| 18 mo |
503.1 ± 41.8 (n = 25) |
501.7 ± 56.3 (n = 12) |
454.5 ± 88.0* (n = 22) |
|
| 24 mo |
587.9 ± 55.7 (n = 14) |
582.8 ± 99.4 (n = 10) |
440.2 ± 107.7*** (n = 16) |
|
| FEF25–75 (ml/s) | 6 mo |
427.6 ± 29.4 (n = 33) |
364.2 ± 53.2*** (n = 10) |
355 ± 60.5*** (n = 25) |
| 12 mo |
523.4 ± 27.1 (n = 25) |
515.5 ± 51.5 (n = 8) |
387.7 ± 66.6*** (n = 20) |
|
| 18 mo |
573.4 ± 31.3 (n = 25) |
554.1 ± 59.5 (n = 12) |
503.8 ± 103.8** (n = 22) |
|
| 24 mo |
637.1 ± 41.8 (n = 14) |
626.4 ± 77.1 (n = 10) |
478.3 ± 108.6*** (n = 16) |
*p < 0.05 compared with the control group; **p < 0.01 compared with the control group; ***p < 0.001 compared with the control group.
Vt, tidal volume; Rrs, resistance of respiratory system, Crs, compliance of respiratory system; V’maxFRC, maximal flow at functional residual capacity; FEV0.5, forced expiratory volume at 0.5 s; FVC, forced vital capacity; FEF25–75, forced midexpiratory flow.