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. 2020 Jan 16;11(1):29. doi: 10.1038/s41419-019-2218-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Masson’s trichrome (upper panels) or Sirius red staining (lower panels) of renal sections among indicated groups. b Immunoblot analyses showing the expression of collagen I and α-SMA in the fibrotic kidneys compared with sham control. c Densitometry analyses of collagen I and α-SMA in immunoblots. GAPDH was used as a loading control. d Representative electron micrographs of mitochondria from renal interstitial fibroblasts among groups as indicated. e Quantitative analysis of mitochondrial length. f Experimental design of evaluating the therapeutic effect of mdivi-1 on established fibrosis. g Immunoblot analyses showing the expression of collagen I and α-SMA in the mdivi-1-treated fibrotic kidneys compared with vehicle control. h Masson’s trichrome (upper panels) or Sirius red staining (lower panels) of kidney sections of the indicated groups. Data in c and e are means ± SEM (n = 6 per group); *p < 0.05 vs sham groups; #p < 0.05 vs vehicle-treated obstructed groups.