Fig. 1. TKT deficiency reduced bile acids in livers.
a Metabolomic analysis of bile acids in livers from mice at 2 months of age. b Mass spectrometric detection of bile acids at 6 months of age in livers from mice following DEN/HFD treatment. c Mass spectrometric detection of bile acids at 6 months of age in serum from mice following DEN/HFD treatment. d QPCR analysis of TKT, FXR, and BSEP mRNA expression in TKT+/+Alb-cre and TKTfl/flAlb-Cre mice livers. Data are presented as mean ± squared error (SEM), the bar indicates the mean. Statistical significance was calculated using two-tailed unpaired t-test, *p < 0.05, **p < 0.01.