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Isobolograms of mixtures of two anaesthetics acting on different sites show synergy. The fractional concentrations of the drugs required to produce 50% LoRR are plotted as in Figure 3. Shown are combinations of (a): etomidate (Eto) and alphaxalone (Alphax), Site 1 and Site 3 anaesthetics, respectively; (b): etomidate and R‐mTFD‐MPAB (MPAB), Site 1 and Site 2 anaesthetics, respectively, and (c): R‐mTFD‐MPAB and alphaxalone, Site 2 and Site 3 anaesthetics, respectively.
