Table 2.

Fixed concentrations, EC₅₀s, and αs of all same‐site anaesthetic mixtures

	Drug A	[Drug A] μM	Drug B	[Drug B] μM	Drug C	[Drug C] μM	α	Average α
Site 1	Etomidate	0.60	Azietomidate	0.77 ± 0.12	—	—	0.90 ± 0.10
		1.00		0.86 ± 0.11	—	—	1.15 ± 0.09
		1.78		0.34 ± 0.07	—	—	1.08 ± 0.06
		1.46 ± 0.16		0.305	—	—	0.91 ± 0.07
		1.05 ± 0.12		0.53	—	—	0.90 ± 0.05
		0.42 ± 0.09		1.20	—	—	1.12 ± 0.04	1.01 ± 0.14
		0.111		1.04 ± 0.15	Carboetomidate	0.27	0.95 ± 0.12
		0.222		0.96 ± 0.54		0.54	0.98 ± 0.12
		0.555		0.34 ± 0.06		1.36	0.78 ± 0.05
		0.111		0.06		4.22 ± 0.55	0.88 ± 0.10
		0.222		0.12		3.51 ± 0.49	0.85 ± 0.09
		0.555		0.305		1.44 ± 0.39	0.77 ± 0.07
		1.93 ± 0.26		0.06		0.27	0.97 ± 0.12
		1.67 ± 0.22		0.12		0.54	0.95 ± 0.10
		1.00 ± 0.13		0.305		1.36	0.95 ± 0.06	0.90 ± 0.12
Site 2	R‐mTFD‐MPAB	0.585	R‐mCF3‐MPAB	6.93 ± 0.85	—	—	1.20 ± 0.12
		1.17		2.75 ± 0.39	—	—	0.88 ± 0.05
		1.755		1.12 ± 0.21	—	—	0.90 ± 0.03
		1.78 ± 0.20		1.82	—	—	1.01 ± 0.09
		1.23 ± 0.12		3.64	—	—	1.03 ± 0.05
		1.20 ± 0.12		5.46	—	—	1.26 ± 0.05	1.05 ± 0.17
		0.12		4.42 ± 0.67	R‐miPr‐MPAB	0.06	0.70 ± 0.09
		0.234		3.39 ± 0.54		0.11	0.66 ± 0.07
		0.585		3.07 ± 0.48		0.29	0.92 ± 0.07
		0.12		0.37		0.97 ± 0.15	0.95 ± 0.13
		0.23		0.73		0.83 ± 0.15	0.93 ± 0.13
		0.585		1.83		0.30 ± 0.04	0.77 ± 0.04
		1.09 ± 0.17		0.37		0.06	0.56 ± 0.07
		1.06 ± 0.13		0.73		0.11	0.65 ± 0.07
		0.82 ± 0.17		1.83		0.285	0.85 ± 0.07	0.78 ± 0.17 a
Site 3	Alphaxalone	0.355	3α5βP	0.28 ± 0.03	—	—	1.16 ± 0.11
		0.71		0.13 ± 0.02	—	—	0.93 ± 0.06
		1.065		0.13 ± 0.03	—	—	1.18 ± 0.10
		1.05 ± 0.12		0.078	—	—	0.99 ± 0.08
		0.85 ± 0.14		0.157	—	—	1.10 ± 0.10
		0.80 ± 0.15		0.235	—	—	1.31 ± 0.11	1.11 ± 0.17
		0.07		0.26 ± 0.04	THDOC	0.125	0.94 ± 0.13
		0.14		0.20 ± 0.03		0.25	0.85 ± 0.10
		0.355		0.13 ± 0.02		0.625	0.92 ± 0.06
		0.07		0.016		1.84 ± 0.35	0.83 ± 0.14
		0.14		0.031		1.34 ± 0.20	0.74 ± 0.08
		0.355		0.078		0.93 ± 0.13	0.87 ± 0.05
		0.86 ± 0.11		0.016		0.125	0.71 ± 0.08
		0.95 ± 0.11		0.031		0.25	0.87 ± 0.08
		0.45 ± 0.08		0.078		0.625	0.82 ± 0.05	0.84 ± 0.12 a

Note. α values are reported as ±SD. SD of average αs are calculated according to Equation (2). Each concentration–response curve had 40 animals.

^aDiffers significantly (P < .01) from the value of one expected for additivity.