Table 4.

Fixed concentrations, EC₅₀s, and αs of propofol with Site 1, 2, and 3 anaesthetics

Drug A	[Drug A] μM	[Propofol] μΜ	α	Average α
Etomidate	0.29 ± 0.03	0.158	0.38 ± 0.01
	0.25 ± 0.03	0.315	0.61 ± 0.01
	0.07 ± 0.02	0.473	0.78 ± 0.01
	0.555	0.09 ± 0.01	0.39 ± 0.02
	1.11	0.03 ± 0.01	0.54 ± 0.01
	1.655	0.01 ± 0.01	0.75 ± 0.01	0.58 ± 0.17 a
R‐mTFD‐MPAB	0.24 ± 0.04	0.158	0.35 ± 0.02
	0.14 ± 0.02	0.315	0.56 ± 0.01
	0.03 ± 0.01	0.473	0.76 ± 0.01
	0.585	0.09 ± 0.01	0.39 ± 0.02
	1.17	0.03 ± 0.01	0.54 ± 0.01
	1.755	0.01 ± 0.01	0.75 ± 0.01	0.56 ± 0.17 a
Alphaxalone	0.34 ± 0.04	0.158	0.59 ± 0.03
	0.29 ± 0.05	0.315	0.79 ± 0.04
	0.09 ± 0.01	0.473	0.84 ± 0.01
	0.355	0.08 ± 0.02	0.33 ± 0.03
	1.710	0.03 ± 0.01	0.53 ± 0.01
	1.065	0.03 ± 0.01	0.78 ± 0.01	0.64 ± 0.20 a

Note. α values are reported as ±SD. SD of average αs are Calculated according to Equation (2). Each concentration–response curve had 40 animals except for the first two rows that had 50 and 55 animals respectively.

^aDiffers significantly (P < .01) from the value of one expected for additivity.