Figure 1.

Profile of circRNAs in PTX-Resistant Ovarian Cancer Tissues

(A) circRNA microarray data of five pairs of PTX-sensitive ovarian cancer tissues and PTX-resistant ovarian cancer tissues are presented in a heatmap. (B) Relative expression of hsa_circ_0063809 in PTX-resistant ovarian cancer. (C) Relative expression of has_circ_0001946 in PTX-resistant ovarian cancer. (D) Relative expression of has_circ_0026134 in PTX-resistant ovarian cancer. (E) Relative expression of hsa_circ_0025033 in PTX-resistant ovarian cancer. (F) Relative expression of hsa_circ_0014130 in PTX-resistant ovarian cancer. (G) Determination of IC₅₀ values of PTX for both resistant cell lines after inhibition of various circRNAs. (H) Relative expression of circCELSR1 in PTX-resistant ovarian cancer and PTX-sensitive ovarian cancer. (I) Relative expression of circCELSR1 in a panel of ovarian cancer cell lines. All tests were at least performed three times. Data are expressed as mean ± SD. **p < 0.01, ***p < 0.001.